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SCHIZOPHRENIA
DEFINITION:-
Schizophrenia
literally means “SPLIT” personality. It would be more appropriate to call it a
split from reality. Actually the patient withdraws himself from reality and
lives in a world of his own, full of false beliefs (delusions which cannot be
corrected by reasoning or logic) and has false perceptions (hallucinations,
sensory experiences mostly auditory which are non-existent) without any obvious
stimulus.
AETIOLOGY OR
CAUSES:-
In
western countries, schizophrenia is a common mental condition, atleast half of
the beds in any mental hospital are occupied by schizophrenia. The aetiology
remains unknown. There are a number of speculations as regards its causation.
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GENETIC
FACTORS:-
It is generally accepted that heredity does
play a decisive role in its causation. The cold, introvert dreamy eccentric who
is oversensitive or suspicious and is unable to deal with the odds of life is
the man who is likely to be affected.
-
PSCHOLOGICAL
STRESS AND ENVIRONMENT:-
As stated above, any psychological stress
is likely to precipitate schizophrenia in a person, strained family or social
relationship may similarly act as a precipitating factor.
-
BIOCHEMICAL
FACTORS:-
There is possibly an over activity of the
dopaminergic neurotransmitter substance in the mesolimbic and mesocortical
areas. Drugs that stimulate dopamine receptors in the CNS (e.g. L-dopa and
amphetamine) are likely to precipitate schizophrenia. Existence of an abnormal
transmitter substance, possibly hallucinogenic in nature, has also been
suspected.
-
CEREBRAL
DAMAGE:-
Schizophrenia evidences of nonspecific type
of atrophic changes in the brain (as deduced from enlargement of the
ventricles) have been detected by CT scan. Schizophrenia like syndrome may be
associated with such CNS disorders as cerebral tumor, demyelinating diseases,
temporal lobe epilepsy and Huntington’s chorea. Role of an unknown virus has
been suspected.
SYMPTOMS:-
The
following features are commonly present.
1.
A decreasing interest in the outside world.
2.
An increasing interest in himself – own
thoughts, bodily symptoms and the past.
3.
Thinking in “own terms” (autistic thinking) –
the thoughts are however, aimless, illogical and inconsistent. His thoughts are
bizarre, irrational and jumbled up.
4.
Talking in “own terms”- he may talk and talk and
talk on any topic whatsoever although his talk has no meaning or correlation
with facts. He may write (and write enthusiastically with a sense of command on
the subject) long letters or long essays on a wide variety of topics ranging
from philosophy to sexology, often with no meaning.
5.
Showing flatness of emotions – he may quickly
listen about the death of a near relative or a close friend and respond with a
smile or shrugging of shoulders and does not seem to bother about it. On the
contrary, he may start sobbing or crying or even turn violent on a trifle thing
like loss of a pen or a match box.
6.
Exhibiting impulsive and inconsistent behavior
and mannerisms.
7.
Living a life of fantasy full of hallucinations,
delusions (usually of bizarre types) and false perceptions.
8.
Prominent feature of schizophrenia is recurrent
remissions and relapses. During a period of remission, the patient behaves and
lives like a normal man. A relapse is, however, bound to occur sooner or later.
TYPES:-
a. SIMPLE TYPE:-
The patient lacks feeling for any emotion
such as sadness or grief, joy or compassion, love or hate. he is dull,
withdrawn, inactive and wishes to live alone.
b. PARANOID TYPE:-
The patient has delusions (or false
beliefs). He is egoistic, argumentative and aggressive due to delusion of
grandeur – the feeling of being important.
c. HEBEPHRENIC TYPE:-
Disorder of thought is the predominant
symptoms. Thoughts are confused and the behavior is purposeless or silly. The
speech is irrational and mannerisms are present. This type of schizophrenia is
more common in males in the early thirties age. The patient gradually becomes
depressed, dull and apathetic, losing all interest in the surroundings.
d. CATATONIC TYPE:-
It is characterized by gross disorders of
motor behavior (such as bizarre postures and activities of a madman) or
terrific excitement alternating with periods of complete inactivity withdrawal
or ever stupor. A peculiar type of muscular rigidity is often present. This is
the commonest type of schizophrenia seen in India.
TREATMENT:-
1. Antipsychotic drugs:-
-
Phenothiazine group of drugs are of great value
and provide the first line of treatment.
-
Chlorpromazine (100-1500 mg daily) or thioridazine
(50-500 mg daily) is used initially (either IM or orally).
-
Trifluperazine (5-30mg daily) may be tried in
cases associated with hallucinations.
-
ECT may be helpful only in cases associated with
depression.
2. Psychotherapy and occupational therapy.
3. Surgical treatment.
HOMEOPATHIC TREATMENT:-
1. ANACARDIUM:-
Hallucinations; thinks he is possessed of
two persons or wills. Syphilitic patients often suffer with these conditions. Anxiety
when walking, as if pursued. Profound melancholy and hypochondriasis, with tendency
to use violent language. Impaired memory. Absent mindedness. Malicious; seems
bent on wickedness. Lack of confidence in himself or others. Suspicious
[Hyos.]. Clairaudient, hears voices far away or of the dead.
2. AURUM METALICUM:-
Feeling of self-condemnation and utter
worthlessness. Profound despondency, with increased blood pressure, with
thorough disgust of life, and thoughts of suicide. Great fear of death. Peevish
and vehement at least contradiction. Anthropophobia. Mental derangements. Constant
rapid questioning without waiting for reply. Cannot do things fast enough. Over
sensitiveness; [Staph.] to noise, excitement, confusion.
3. KALI BROMATUM:-
Profound, melancholic delusion; feeling of
moral deficiency; religious depression; delusions of conspiracies against him. Imagines
he is singled out as an object of divine wrath. Loss of memory. Must do
something-move about; gets fidgety. [Tarant.]. Amnesic aphasia; can pronounce
any word told, but cannot speak otherwise. Active delirium. Horrid illusions. Night
terrors. General failure of mental power, loss of memory, melancholia,
anaesthesia of the mucus membranes, especially of eyes, throat, and skin; acne;
loss of sexual desire, paralysis.
4. LACHESIS:-
Sad in the morning; no desire to mix with
the world. Mental labor best performed at night. Great loquacity. Suspicious;
nightly delusion of fire. Religious insanity. [Verat.; Stram.]. Derangement of
the time sense. Restless and uneasy; does not wish to attend to business; wants
to be off somewhere all the time. Jealous. [Hyos.].
5. STRAMONIUM:-
Devout, earnest, beseeching and ceaseless
talking. Loquacious, garrulous, laughing, singing, swearing, praying, rhyming. Sees
ghosts, hears voices, talks with spirits. Rapid changes from joy to sadness. Delusions
about his identity; thinks himself tall, double, a part missing. Cannot bear
solitude or darkness; must have light and company. Sight of water or anything
glittering brings on spasms. Delirium, with desire to escape. [Bell. Bry;
Rhus.]. Religious mania.
6. HYOSCYAMUS:-
It is as if some diabolical force took
possession of the brain and prevented its functions. Very suspicious. Talkative,
obscene, lascivious mania, uncovers body; jealous, foolish. Great hilarity;
inclined to laugh at everything. Delirium, with attempt to run away. Low,
muttering speech; constant carphologia, deep stupor.
7. BELLADONNA:-
Patient lives in a world of his own,
engrossed by specters and visions and oblivious to surrounding realities. While
the retina is insensible to actual objects, a host of visual
Hallucinations throng about him and come to
him from within. He is acutely alive and crazed by a flood of subjective visual
impressions and fantastic illusions. Hallucinations; sees monsters, hideous
faces. Delirium; frightful images; furious; rages, bites, strikes; desire to
escape. Loss of consciousness. Perversity, with tears. Changeableness. Disinclined
to talk.
8. CHINA OFFICINALIS:-
Discontent; the patient deems himself
unfortunate, and ill-used by the whole world. Great abundance of ideas, and of
projects, with slow progress of thought (especially in the evening and at
night). Fear of dogs and of other animals, especially at night. Excessive
irascibility, with pusillanimity, and inability to bear the least noise. Disobedience.
Hypochondriacal dejection. Apathy and moral insensibility.
9. COCAINA:-
Talkative. Constant desire to do something
great, to undertake vast feats of strength. Frightful persecutory
hallucinations; sees and feels bugs and worms. Personal appearance neglected. Thinks
he hears unpleasant remarks about himself. Hallucinations of hearing. Insomnia.
Cerebral activity. Moral sense blunted.
Some of other drugs for schizophrenia are ignitia, nux vomica, rhus toxi, sulphur,
zincum met, veratrum album, silicea, opium, lycopodium and helliborus.
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